Rab4 (18S8) Rabbit Monoclonal Antibody

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Catalog Number:MABN16789
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Rab4
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,ICC/IF 1:200-1:1000,FC 1:100-1:200,IP 1:10-1:100
Molecular Weight:24kDa
Purification:Affinity purification
Form:Liquid
Synonyms:Rab4 ; RAB4A; HRES 1 ;RAB4; Ras related protein Rab 4A;

Applications

WB 1:1000-1:5000,ICC/IF 1:200-1:1000,FC 1:100-1:200,IP 1:10-1:100

Immunogen

A synthetic peptide of human Rab4

Target Background

The protein encoded by this gene belongs to the rab family. Rab4A protein is involved in the regulation of procathepsin L secretion, it was either inhibited by expression of a Rab4A dominant-negative mutant or increased by overexpression of the wild-type Rab4A in human melanoma cells. Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420). Involved in protein transport (PubMed:29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha- granule release during activation and aggregation of platelets (By similarity).

Synonyms:Rab4 ; RAB4A; HRES 1 ;RAB4; Ras related protein Rab 4A;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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