Immunological Sciences

RAGE Rabbit Monoclonal Antibody

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Catalog Number:MABN02516
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human RAGE
Reactivity:Mouse
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 43 kDa; Observed MW: 55 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products

Applications

WB 1:500-1:1000

Immunogen

Recombinant protein of human RAGE

Target Background

The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. Mediates interactions of advanced glycosylation end products (AGE). Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Synonyms:AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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