RAPGEF5 Rabbit Monoclonal Antibody

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Catalog Number:MABN87658
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human RAPGEF5
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:10-1:100
Molecular Weight:Calculated MW:68 kDa; Observed MW:68-75 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:GFR; REPAC; MR-GEF

Applications

WB 1:1000-1:5000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:10-1:100

Immunogen

A synthetic peptide of human RAPGEF5

Target Background

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Synonyms:GFR; REPAC; MR-GEF

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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