Immunological Sciences

RGMA Rabbit Monoclonal Antibody

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Catalog Number:MABN84676
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human Repulsive guidance molecule A
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000,ICC 1:50-1:200
Molecular Weight:Calculated MW: 49 kDa ; Observed MW: 37 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;;Repulsive guidance molecule A

Applications

WB 1:1000-1:2000,ICC 1:50-1:200

Immunogen

A synthesized peptide derived from human Repulsive guidance molecule A

Target Background

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition.

Synonyms:Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;;Repulsive guidance molecule A

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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