Immunological Sciences

RICTOR Monoclonal Antibody

Immunohistochemistry of paraffin-embedded human lung cancer using (RICTOR antibody) at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung cancer using (RICTOR antibody) at dilution of 1:100

Catalog Number:MAB-94699
Conjugate:Unconjugated
Size:100UG
Concentration:53A2
Host:Rb
Isotype:IgG
Clone:MONO
Immunogen:rapamycin-insensitive companion of mTOR
Reactivity:Hu, Ms, Rt
Applications:WB: 1:1000-1:5000; IHC: 1:50-1:2
Molecular Weight:192 kDa
Purification:Aff. Pur.
Form:Liquid
Synonyms:AVO3 homolog, hAVO3, KIAA1999, mAVO3, RICTO

Applications

WB: 1:1000-1:5000; IHC: 1:50-1:2

Immunogen

rapamycin-insensitive companion of mTOR

Target Background

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient - insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development

Synonyms:AVO3 homolog, hAVO3, KIAA1999, mAVO3, RICTO

Storage

-20° for 12months

Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3

Immunohistochemistry of paraffin-embedded human lung cancer using (RICTOR antibody) at dilution of 1:100

HEK-293 cells were subjected to SDS PAGE followed by western blot with (RICTOR antibody) at dilution of 1:4000

Immunohistochemistry of paraffin-embedded human lung cancer using (RICTOR antibody) at dilution of 1:100

HEK-293 cells were subjected to SDS PAGE followed by western blot with (RICTOR antibody) at dilution of 1:4000

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