Immunological Sciences

RIP Rabbit Monoclonal Antibody

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Catalog Number:MABN86877
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse RIP
Reactivity:Mouse
Applications:WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50
Molecular Weight:Calculated MW:75 kDa; Observed MW:75 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:RIP; Rinp; Rip1; D330015H01Rik

Applications

WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50

Immunogen

Recombinant protein of mouse RIP

Target Background

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.

Synonyms:RIP; Rinp; Rip1; D330015H01Rik

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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