Immunological Sciences

RIPK3 Mouse Monoclonal Antibody

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Catalog Number:MABN86115
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.
Reactivity:Human
Applications:WB 1:500-1:2000
Molecular Weight:56.9kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

Applications

WB 1:500-1:2000

Immunogen

This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.

Target Background

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Synonyms:Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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