Immunological Sciences

RNA Polymerases I/II/III Subunit ABC1 Rabbit Monoclonal Antibody

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Catalog Number:MABN02457
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human POLR2E
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,IHC 1:50-1:100
Molecular Weight:Calculated MW: 25 kDa; Observed MW: 25 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:RPB5; XAP4; RPABC1; hRPB25; hsRPB5

Applications

WB 1:500-1:1000,IHC 1:50-1:100

Immunogen

A synthetic peptide of human POLR2E

Target Background

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process .

Synonyms:RPB5; XAP4; RPABC1; hRPB25; hsRPB5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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