RNF8 Rabbit Monoclonal Antibody

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Catalog Number:MABN84009
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human RNF8
Reactivity:Human,Rat
Applications:WB 1:1000-1:2000
Molecular Weight:Calculated MW: 56 kDa ; Observed MW: 60 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:C3HC4 type zinc finger protein; RNF8;;RNF8

Applications

WB 1:1000-1:2000

Immunogen

A synthesized peptide derived from human RNF8

Target Background

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.

Synonyms:C3HC4 type zinc finger protein; RNF8;;RNF8

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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