Immunological Sciences

SET7 Rabbit Monoclonal Antibody

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Catalog Number:MABN86923
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human SET7
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IP 1:50-1:200
Molecular Weight:Calculated MW:41 kDa; Observed MW:41 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:KMT7; SET7; SET9; SET7/9

Applications

WB 1:1000-1:5000,IP 1:50-1:200

Immunogen

A synthetic peptide of human SET7

Target Background

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Synonyms:KMT7; SET7; SET9; SET7/9

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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