SETD7 Mouse Monoclonal Antibody

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Catalog Number:MABN82270
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2a
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.
Reactivity:Human,Rat,Monkey
Applications:WB 1:500-1:2000,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:40.7kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:KMT7; SET7; SET9; SET7/9

Applications

WB 1:500-1:2000,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.

Target Background

Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Synonyms:KMT7; SET7; SET9; SET7/9

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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