SIGIRR Rabbit Monoclonal Antibody

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Catalog Number:MABN87787
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human SIGIRR
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:46 kDa; Observed MW:75-100 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TIR8; IL-1R8

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human SIGIRR

Target Background

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Synonyms:TIR8; IL-1R8

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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