Smad2 (19V12) Rabbit Monoclonal Antibody

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Catalog Number:MABN17989
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Smad2
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:200
Molecular Weight:52kDa
Purification:Affinity purification
Form:Liquid
Synonyms:JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2; Smad 2;

Applications

WB 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:50-1:200

Immunogen

A synthetic peptide of human Smad2

Target Background

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Synonyms:JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2; Smad 2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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