Immunological Sciences

SNAI1 Mouse Monoclonal Antibody

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Catalog Number:MABN80931
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human SNAI1 expressed in E. Coli.
Reactivity:Human
Applications:WB 1:500-1:1000,ELISA 1:5000-1:20000
Molecular Weight:29kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1

Applications

WB 1:500-1:1000,ELISA 1:5000-1:20000

Immunogen

Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Target Background

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Synonyms:SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Ascitic fluid containing 0.03% sodium azide.

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