Immunological Sciences

SNAI1 Rabbit Polyclonal Antibody

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Catalog Number:ABN03386
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human SNAI1. AA range:215-264
Reactivity:Human,Mouse
Applications:WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000
Molecular Weight:Calculated MW: 29 kDa; Observed MW: 29 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna

Applications

WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human SNAI1. AA range:215-264

Target Background

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Synonyms:SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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