SnoN Rabbit Polyclonal Antibody

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Catalog Number:ABN18058
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000
Molecular Weight:77kDa
Purification:Affinity purification
Form:Liquid
Synonyms:SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

Applications

WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000

Immunogen

The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Target Background

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],function:May have regulatory role in cell division or differentiation in response to extracellular signals.,similarity:Belongs to the SKI family.,subunit:Interacts with SMAD2, SMAD3 and RNF111.,tissue specificity:SNON and SNOA isoforms are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Expression of isoform SNOI is restricted to skeletal muscle.,

Synonyms:SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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