Immunological Sciences

SPHK1 (Phospho-Ser225) Rabbit Polyclonal Antibody

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Catalog Number:ABN06084
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:Synthesized peptide derived from human SPHK1 (Phospho-Ser225)
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000
Purification:Affinity purification
Form:Liquid
Synonyms:Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91)

Applications

WB 1:500-1:2000

Immunogen

Synthesized peptide derived from human SPHK1 (Phospho-Ser225)

Target Background

catalytic activity:ATP + sphinganine = ADP + sphinganine 1-phosphate.,catalytic activity:ATP + sphingosine = ADP + sphingosine 1-phosphate.,cofactor:Magnesium.,function:Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.,similarity:Contains 1 DAGKc domain.,subunit:Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP.,tissue specificity:Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.,

Synonyms:Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91)

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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