Sprouty 2 (4O5) Rabbit Monoclonal Antibody

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Catalog Number:MABN18214
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Spry-2
Reactivity:Human,Rat
Applications:WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200
Molecular Weight:35kDa
Purification:Affinity purification
Form:Liquid
Synonyms:hSPRY2; Sprouty2; SPRY2;

Applications

WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200

Immunogen

A synthetic peptide of human Spry-2

Target Background

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB- induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).

Synonyms:hSPRY2; Sprouty2; SPRY2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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