Immunological Sciences

STAT5A/B Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN21278
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG,Kappa
Clone:Monoclonal
Reactivity:Human,Mouse,Rat,
Applications:WB 1:2000-1:10000,IHC 1:2000-1:8000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200
Molecular Weight:CalcuLated MW:91kD;Observed MW:100kD
Purification:Protein A
Form:Liquid
Synonyms:STAT5A;STAT5;Signal transducer and activator of transcription 5A;STAT5B;Signal transducer and activator of transcription 5B

Applications

WB 1:2000-1:10000,IHC 1:2000-1:8000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200

Target Background

Cell localization:Cytoplasm, Nucleus.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been

Synonyms:STAT5A;STAT5;Signal transducer and activator of transcription 5A;STAT5B;Signal transducer and activator of transcription 5B

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

No documents available.