Tcl1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86659
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Tcl1
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:100-1:1000,ICC/IF 1:100-1:200,FC 1:200-1:500
Molecular Weight:Calculated MW:14 kDa; Observed MW:14 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TCL1

Applications

WB 1:1000-1:5000,IHC 1:100-1:1000,ICC/IF 1:100-1:200,FC 1:200-1:500

Immunogen

A synthetic peptide of human Tcl1

Target Background

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Synonyms:TCL1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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