Immunological Sciences

Tensin-1 Rabbit Polyclonal Antibody

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Catalog Number:ABN18793
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human Tensin-1. AA range:1273-1322
Reactivity:Human,Mouse
Applications:WB 1:500-1:2000,ELISA 1:5000-1:20000
Molecular Weight:200kDa
Purification:Affinity purification
Form:Liquid
Synonyms:TNS1; TNS; Tensin-1

Applications

WB 1:500-1:2000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human Tensin-1. AA range:1273-1322

Target Background

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],function:May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.,PTM:Rapidly cleaved by calpain II.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.,tissue specificity:Ubiquitous.,

Synonyms:TNS1; TNS; Tensin-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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