Immunological Sciences

Thyroglobulin (4G11) Rabbit Monoclonal Antibody

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Catalog Number:MABN18911
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Thyroglobulin
Reactivity:Human
Applications:WB 1:2000-1:20000,IHC 1:200-1:500
Molecular Weight:305kDa
Purification:Affinity purification
Form:Liquid
Synonyms:AITD3; hTG; TDH3; Tg; TGN; Thyroglobulin;

Applications

WB 1:2000-1:20000,IHC 1:200-1:500

Immunogen

A synthetic peptide of human Thyroglobulin

Target Background

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030).

Synonyms:AITD3; hTG; TDH3; Tg; TGN; Thyroglobulin;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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