Immunological Sciences

TIMP1 (9Y15) Rabbit Monoclonal Antibody

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Catalog Number:MABN18949
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human TIMP1
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:200-1:500
Molecular Weight:23kDa
Purification:Affinity purification
Form:Liquid
Synonyms:EPO; EPA; TIMP1; CLGI;

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:200-1:500

Immunogen

Recombinant protein of human TIMP1

Target Background

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Synonyms:EPO; EPA; TIMP1; CLGI;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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