TNF Receptor II (19A16) Rabbit Monoclonal Antibody

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Catalog Number:MABN19083
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TNF Receptor II
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50,FC 1:20-1:100,IP 1:10-1:100
Molecular Weight:48kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; Tnfrsf1b;

Applications

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50,FC 1:20-1:100,IP 1:10-1:100

Immunogen

A synthetic peptide of human TNF Receptor II

Target Background

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Synonyms:CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; Tnfrsf1b;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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