Immunological Sciences

TRADD (1A3) Rabbit Monoclonal Antibody

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Catalog Number:MABN19179
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TRADD
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:100,FC 1:20-1:50
Molecular Weight:34kDa
Purification:Affinity purification
Form:Liquid
Synonyms:AA930854; TNFR1 associated DEATH domain protein; tradd;

Applications

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:100,FC 1:20-1:50

Immunogen

A synthetic peptide of human TRADD

Target Background

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153). Overexpression of TRADD leads to two major TNF- induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).

Synonyms:AA930854; TNFR1 associated DEATH domain protein; tradd;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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