Immunological Sciences

TRAF2 (15T4) Rabbit Monoclonal Antibody

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Catalog Number:MABN19183
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TRAF2
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:50-1:200,IP 1:20-1:50
Molecular Weight:56kDa
Purification:Affinity purification
Form:Liquid
Synonyms:TNF receptor associated factor 2; TRAF2; TRAP; TRAP3;

Applications

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:50-1:200,IP 1:20-1:50

Immunogen

A synthetic peptide of human TRAF2

Target Background

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Synonyms:TNF receptor associated factor 2; TRAF2; TRAP; TRAP3;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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