TRIM23 Rabbit Monoclonal Antibody

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Catalog Number:MABN02717
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TRIM23
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 64 kDa; Observed MW: 64 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ARD1; ARFD1; RNF46

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human TRIM23

Target Background

Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).

Synonyms:ARD1; ARFD1; RNF46

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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