Immunological Sciences

TRIM24 Rabbit Monoclonal antibody

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Catalog Number:MABN02718
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TRIM24
Reactivity:Human
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 117 kDa; Observed MW: 117 kDa
Purification:Affinity Purified
Form:Liquid
Synonyms:PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human TRIM24

Target Background

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes .

Synonyms:PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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