TRIM29 (18R2) Rabbit Monoclonal Antibody

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Catalog Number:MABN19272
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human TRIM29
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000
Molecular Weight:66kDa
Purification:Affinity purification
Form:Liquid
Synonyms:ATDC; TRIM29;

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human TRIM29

Target Background

It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line. Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Synonyms:ATDC; TRIM29;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

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