TRIM29 Rabbit Monoclonal Antibody

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Catalog Number:MABN84310
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human TRIM29
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000
Molecular Weight:Calculated MW: 66 kDa ; Observed MW: 68 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ATDC; TRIM29;;TRIM29

Applications

WB 1:1000-1:2000

Immunogen

A synthesized peptide derived from human TRIM29

Target Background

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Synonyms:ATDC; TRIM29;;TRIM29

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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