Immunological Sciences

TTF1 (17D1) Rabbit Monoclonal Antibody

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Catalog Number:MABN19399
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human TTF1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:200-1:500
Molecular Weight:39kDa
Purification:Affinity purification
Form:Liquid
Synonyms:BCH; BHC; NK2; NKX2.1; NKX2A; TEBP; Thyroid nuclear factor 1; Tinman; TITF1; TTF1;

Applications

WB 1:1000-1:5000,IHC 1:200-1:500

Immunogen

Recombinant protein of human TTF1

Target Background

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).

Synonyms:BCH; BHC; NK2; NKX2.1; NKX2A; TEBP; Thyroid nuclear factor 1; Tinman; TITF1; TTF1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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