Tuberin Rabbit Monoclonal Antibody

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Catalog Number:MABN83799
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human Tuberin
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100
Molecular Weight:Calculated MW: 201 kDa ; Observed MW: 200 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TSC2; Tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberin;;Tuberin

Applications

WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100

Immunogen

A synthesized peptide derived from human Tuberin

Target Background

Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1.

Synonyms:TSC2; Tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberin;;Tuberin

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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