UBA3 Rabbit Monoclonal Antibody

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Catalog Number:MABN84768
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthesized peptide derived from human UBA3
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:2000
Molecular Weight:Calculated MW: 52 kDa ; Observed MW: 50 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:hUba3; NEDD8 activating enzyme E1C; uba3; UBE1C;;UBA3

Applications

WB 1:1000-1:2000

Immunogen

A synthesized peptide derived from human UBA3

Target Background

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Synonyms:hUba3; NEDD8 activating enzyme E1C; uba3; UBE1C;;UBA3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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