Immunological Sciences

ULK1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86730
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human ULK1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:100-1:200
Molecular Weight:Calculated MW:113 kDa; Observed MW:130 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ATG1; ATG1A; UNC51; hATG1; Unc51.1

Applications

WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:100-1:200

Immunogen

A synthetic peptide of human ULK1

Target Background

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Synonyms:ATG1; ATG1A; UNC51; hATG1; Unc51.1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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