Immunological Sciences

VAMP-4 Rabbit Polyclonal Antibody

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Catalog Number:ABN19706
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50
Reactivity:Human,Mouse
Applications:ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000
Purification:Affinity purification
Form:Liquid
Synonyms:VAMP4; Vesicle-associated membrane protein 4; VAMP-4

Applications

ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50

Target Background

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008],function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A.,

Synonyms:VAMP4; Vesicle-associated membrane protein 4; VAMP-4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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