Immunological Sciences

VAMP8 (N-term) Mouse Monoclonal Antibody

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Catalog Number:MABN85966
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This VAMP8 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 2~24 amino acids from the N-terminal region of human VAMP8.
Reactivity:Human
Applications:WB 1:1000-1:2000,IHC 1:100-1:500
Molecular Weight:11.4kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, EDB, VAMP8

Applications

WB 1:1000-1:2000,IHC 1:100-1:500

Immunogen

This VAMP8 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 2~24 amino acids from the N-terminal region of human VAMP8.

Target Background

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.

Synonyms:Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, EDB, VAMP8

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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