VAV1 Mouse Monoclonal Antibody

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Catalog Number:MABN81156
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
Reactivity:Human
Applications:WB 1:250-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:98.3kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:VAV

Applications

WB 1:250-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Target Background

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Synonyms:VAV

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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