Wnt5a Rabbit Polyclonal Antibody

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Catalog Number:ABN00192
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:A synthetic peptide of human Wnt5a
Reactivity:Human
Applications:WB 1:500-1:1000,ICC/IF 1:50-1:200,FC 1:50-1:100
Molecular Weight:Calculated MW: 42 kDa; Observed MW: 42 kDa
Purification:Affinity Chromatography
Form:Liquid
Synonyms:WNT5A; Protein Wnt-5a

Applications

WB 1:500-1:1000,ICC/IF 1:50-1:200,FC 1:50-1:100

Immunogen

A synthetic peptide of human Wnt5a

Target Background

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression.

Synonyms:WNT5A; Protein Wnt-5a

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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