Immunological Sciences

WRN Rabbit Monoclonal Antibody

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Catalog Number:MABN86692
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human WRN
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:163 kDa; Observed MW:200 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:RECQ3; RECQL2; RECQL3; Werner's syndrome helicase WRN; DNA helicase, RecQ-like type 3; RecQ protein-like 2; Werner syndrome protein

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human WRN

Target Background

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

Synonyms:RECQ3; RECQL2; RECQL3; Werner's syndrome helicase WRN; DNA helicase, RecQ-like type 3; RecQ protein-like 2; Werner syndrome protein

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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