Immunological Sciences

XRN1 Mouse Monoclonal Antibody

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Catalog Number:MABN86027
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:This XRN1 antibody is generated from a mouse immunized with arecombinant protein between1455-1706 amino acids from human XRN1.
Reactivity:Human, Mouse
Applications:WB 1:1000-1:2000
Molecular Weight:194.1kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1

Applications

WB 1:1000-1:2000

Immunogen

This XRN1 antibody is generated from a mouse immunized with arecombinant protein between1455-1706 amino acids from human XRN1.

Target Background

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

Synonyms:5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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