Immunological Sciences

YAP Rabbit Polyclonal Antibody

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Catalog Number:ABN19982
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human YAP. AA range:281-330
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:10000
Molecular Weight:67kDa
Purification:Affinity purification
Form:Liquid
Synonyms:YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65

Applications

WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:10000

Immunogen

The antiserum was produced against synthesized peptide derived from human YAP. AA range:281-330

Target Background

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,

Synonyms:YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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