ZAP70 Mouse Monoclonal Antibody

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Catalog Number:MABN80539
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human ZAP70 expressed in E. Coli.
Reactivity:Human
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,ELISA 1:5000-1:20000
Molecular Weight:70kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:SRK; STD; TZK

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,ELISA 1:5000-1:20000

Immunogen

Purified recombinant fragment of human ZAP70 expressed in E. Coli.

Target Background

ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Synonyms:SRK; STD; TZK

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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